RA375 |
| رقم الكتالوجGC62399 |
RA375 هو مثبط RPN13 (الوحدة الفرعية التنظيمية للبروتياز 26S)ينشط RA375 إشارات UPR وإنتاج ROS وموت الخلايا المبرمجيُظهر RA375 نشاطًا أكبر بعشرة أضعاف ضد خطوط السرطان مقارنة بـ RA190 ، مما يعكس بدائل حلقة النيترو وإضافة رأس حربي كلورو أسيتاميد
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].
RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].
[1]. Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.
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