(Rac)-CFT7455 (Synonyms: (Rac)-CFT7455) |
| رقم الكتالوجGC65477 |
(Rac) -CFT7455 هو عامل نسخ إصبع الزنك Ikaros (IKZF1) و Aiolos (IKZF3) ، يعمل عبر مسار البروتيازوم يوبيكويتين ، مع GI50 من 0.05 نانومتر لخلايا NCIH929.1(Rac) -CFT7455 هو أيزومر راسيمي لـ CFT7455 وهو مادة تحلل IKZF1 / IKZF3 مع نشاط مضاد للسرطان
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Cas No.: 2504233-68-3
Sample solution is provided at 25 µL, 10mM.
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(Rac)-CFT7455 is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-CFT7455 is the racemic isomer of CFT7455 which is a IKZF1/IKZF3 degrader with anticancer activity[1][2].
[1]. David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)
[2]. James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
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