1-Alaninechlamydocin |
| رقم الكتالوجGC41984 |
1-Alaninechlamydocin ، رباعي ببتيد دوري ، هو مثبط قوي لـ HDAC (IC50 = 6.4 نانومتر)1-Alaninechlamydocin يحث على إيقاف دورة الخلية G2 / M وموت الخلايا المبرمج في خلايا MIA PaCa-2
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Cas No.: 141446-96-0
Sample solution is provided at 25 µL, 10mM.
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1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
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