1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Synonyms: 1-Palmitoyl-2-Oleoyl-sn-glycero-3-Phosphocholine, 1,2POPC)

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC(POPC) is a phospholipid, it can be used for liposome production in order to study the properties of lipid bilayers^[1]. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC molecule consists of a glycerol backbone, which contains a saturated chain at the sn-1 position (palmitic acid) and an unsaturated chain at the sn-2 position (oleic acid) , the sn-3 position is connected to the phosphocholine head group^[2]. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is associated with the alveolar membrane and is a pulmonary surfactant^[3].

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is prepared into a liposome preparation and fused with HUVEC cells to monitor the coagulation process induced by interleukin 1^[4]. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC was prepared into a liposome preparation, which can be used to determine the lipid-binding activity of monogalactosyldiacylglycerol synthase (MGD1) in plant samples ^[5].1-Palmitoyl-2-oleoyl-sn-glycero-3-PC, as a phospholipid bilayer membrane, can also be used to study the kinetic mechanism of drug molecules permeating the cell membrane ^[6].

References:
[1] Moreno M J, Estronca L M B B, Vaz W L C. Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes[J]. Biophysical journal, 2006, 91(3): 873-881.
[2] Van Hoogevest P, Wendel A. The use of natural and synthetic phospholipids as pharmaceutical excipients[J]. European journal of lipid science and technology, 2014, 116(9): 1088-1107.
[3] Qiao L, Ge A, Liang Y, et al. Oxidative degradation of the monolayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in low-level ozone[J]. The Journal of Physical Chemistry B, 2015, 119(44): 14188-14199.
[4] Wiiger M T, Pringle S, Pettersen K S, et al. Effects of binding of ligand (FVIIa) to induced tissue factor in human endothelial cells[J]. Thrombosis research, 2000, 98(4): 311-321.
[5] Dubots E, Audry M, Yamaryo Y, et al. Activation of the chloroplast monogalactosyldiacylglycerol synthase MGD1 by phosphatidic acid and phosphatidylglycerol[J]. Journal of Biological Chemistry, 2010, 285(9): 6003-6011.
[6] BIAN F Y, ZHANG J W, WANG D, et al. Molecular dynamics simulation of the permeation of methyldopa through POPC phospholipid bilayer membrane[J]. Acta Physico-Chimica Sinica, 2014, 30(10): 1947-1956.