2-Amino-3-methylimidazo[4,5-f]quinoline (Synonyms: IQ) |
| رقم الكتالوجGC40707 |
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke.
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![2-Amino-3-methylimidazo[4,5-f]quinoline التركيب الكيميائي](/media/struct/GC4/GC40707.png "2-Amino-3-methylimidazo[4,5-f]quinoline التركيب الكيميائي")
Cas No.: 76180-96-6
Sample solution is provided at 25 µL, 10mM.
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2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke. In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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