2'-Deoxy-2'-fluorocytidine |
| رقم الكتالوجGC61756 |
2'-Deoxy-2'-fluorocytidine ، نظير نيوكليوزيد ، هو مثبط قوي لتكاثر فيروس حمى القرم والكونغو النزفية (CCHFV)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10212-20-1
Sample solution is provided at 25 µL, 10mM.
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2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].
[1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
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