4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) (Synonyms: 4,5-DCQA, Isochlorogenic Acid C) |
| رقم الكتالوجGC33912 |
4،5-Dicaffeoylquinic acid (حمض Isochlorogenic C) (حمض Isochlorogenic C) هو أحد مضادات الأكسدة ، ويمكن عزله عن Gynura divaricata و Laggera alata.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57378-72-0
Sample solution is provided at 25 µL, 10mM.
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4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C) possesses potent hepatoprotective and anti-HBV effects.IC50 value:Target: Anti-hepatitis natural produce.In vitro: To study anti-hepatitis effect of isochlorogenic acid C, anti-apoptotic and anti-injury properties of test compound were evaluated. The results showed that test compound at concentrations of 10 to 100 μg/ml significantly reduced the caspase-3 and transformed growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes. Also, test compound improved markedly cell viability of the D-GalN-injured hepatocytes and produced a maximum protection rate of 47.28% at a concentration of 100 μg/ml. Furthermore, test compound significantly inhibited productions of HBsAg and HBeAg. Its maximum inhibitory rates on the HBsAg and HBeAg expressions were 86.93 and 59.79%, respectively. In addition, test compound significantly induced the HO-1 expression of HepG2.2.15 cells [1]. In vivo:
[1]. Shaoqing Hu, et al.Evaluation of anti-apoptotic, anti-injury and antihepatitis B virus effects of isochlorogenic acid C in vitro. Journal of Medicinal Plants Research Vol. 6(16), pp. 3199-3206 30 April, 2012
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