7ACC2 |
| رقم الكتالوجGC14642 |
7ACC2 هو مثبط قوي لنقل أحادي الكربوكسيل (MCT) مع IC لـ 11 نانومتر لتثبيط [14 درجة مئوية] تدفق اللاكتات7ACC2 هو أيضًا مثبط قوي لنقل بيروفات الميتوكوندريا7ACC2 هو عامل مضاد للسرطان من خلال تثبيط تدفق اللاكتات
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Cas No.: 1472624-85-3
Sample solution is provided at 25 µL, 10mM.
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7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.
References:
[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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