(•)-Drimenol (Synonyms: NSC 169775)

(-)-Drimenol is a sesquiterpene alcohol originally isolated from B. trilobata that has antimicrobial and anticancer activities.1,2,3 It is active against the bacteria S. aureus, B. cereus, A. baumanii, E. coli, and P. aeruginosa (MICs = 667, 667, 583, 1,333, and 667 μg/ml, respectively), as well as the fungi C. cucumerinum and S. tritici (IC50s = 6.6 and 80.1 μg/ml, respectively).1,2 (-)-Drimenol decreases the proliferation of A2058 and A375 melanoma cell lines with IC50 values of 33.5 and 31.25 μg/ml, respectively.3

|1. Santos, T.G., Dognnini, J., Begnini, I.M., et al. Chemical characterization of essential oils from Drimys angustifolia miers (winteraceae) and antibacterial activity of their major compounds. J. Braz. Chem. Soc. 24(1), 164-170 (2013).|2. Scher, J.M., Speakman, J.B., Zapp, J., et al. Bioactivity guided isolation of antifungal compounds from the liverwort Bazzania trilobata (L.) S.F. Gray. Phytochemistry 65(18), 2583-2588 (2004).|3. Russo, A., Cardile, V., Graziano, A.C.E., et al. Antigrowth activity and induction of apoptosis in human melanoma cells by Drymis winteri forst extract and its active components. Chem. Biol. Interact. 305, 79-85 (2019).