BCRP-IN-1 |
رقم الكتالوجGC33099 |
BCRP-IN-1 هو مثبط لبروتين مقاومة سرطان الثدي (BCRP) مع IC50 من 0.6 μ ؛ M على ناقل تدفق BCRP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1699720-85-8
Sample solution is provided at 25 µL, 10mM.
BCRP-IN-1 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.
BCRP-IN-1 (Compound A) shows the potency and a potent pharmacokinetic (PK) profile in rats (lower clearance [1.54 L/h/kg] and higher bioavailability [123%]). XL388 has moderate terminal elimination half-life with t1/2s of 0.9 h and 2.0 h for 2 mg/kg (iv) and 20 mg/kg (po) in rats, respectively[1].
[1]. Li Y, et al. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2016 Jan 15;26(2):551-555.
Average Rating: 5
(Based on Reviews and 24 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *