Becampanel (AMP 397) (Synonyms: AMP 397) |
رقم الكتالوجGC33723 |
Becampanel (AMP 397) (AMP397) هو أول مضاد AMPA تنافسي وعامل مضاد للصرع.
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Cas No.: 188696-80-2
Sample solution is provided at 25 µL, 10mM.
Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.
Becampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9[1].
Becampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo[1].
[1]. Suter W, et al. Genotoxicity assessment of the antiepileptic drug AMP397, an Ames-positive aromatic nitro compound. Mutat Res. 2002 Jul 25;518(2):181-94.
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