BSJ-04-132 |
| رقم الكتالوجGC50614 |
BSJ-04-132 عبارة عن PROTAC متصل بواسطة روابط لـ Cereblon و CDKBSJ-04-132 عبارة عن مطهر CDK4 قوي وانتقائي قائم على Ribociclib (PROTAC) ، مع IC50s من 50.6 نانومتر و 30 نانومتر لـ CDK4 / D1 و CDK6 / D1 ، على التواليBSJ-04-132 لا يسبب تدهور CDK6 و IKZF1 / 3BSJ-04-132 له نشاط مضاد للسرطان
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Cas No.: 2349356-39-2
Sample solution is provided at 25 µL, 10mM.
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Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID:30802347
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