CBM 301940 |
| رقم الكتالوجGC50421 |
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 902146-11-6
Sample solution is provided at 25 µL, 10mM.
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Potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.
Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID:15105298 |Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID:16821767
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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