CHR 6494 trifluoroacetate |
| رقم الكتالوجGC50145 |
CHR 6494 trifluoroacetate هو مثبط قوي لمركب الهاسبين ، مع IC 50 من 2 نانومتر. يثبط CHR 6494 trifluoroacetate الفسفرة هيستون H3T3. يحث CHR 6494 trifluoroacetate على موت الخلايا المبرمج للخلايا السرطانية ، بما في ذلك الورم الميلانيني وسرطان الثدي. يمكن استخدام CHR 6494 trifluoroacetate في أبحاث السرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1458630-17-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.
Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID:21804608
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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