Coralyne chloride |
رقم الكتالوجGC61965 |
كلوريد كورالين هو قلويد بروتوبربيرين مع أنشطة قوية لمكافحة السرطانيعمل كلوريد كورالين كسم قوي لإيزوميراز I ويحث على انقسام الحمض النووييمكن استخدام كلوريد كورالين لتحضير مشتقات كورالين كمجسات فلورية ملزمة للحمض النووي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 38989-38-7
Sample solution is provided at 25 µL, 10mM.
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes[3].
Coralyne (6.25-100 µM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC50s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC50s of 21.9 uM, 19.1 uM, and 91 µM, respectively at 72 hours[1].Coralyne (25 µM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively[1].
References:
[1]. Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445.
[2]. D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91.
[3]. P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667.
Average Rating: 5
(Based on Reviews and 15 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *