DC41-SMe |
| رقم الكتالوجGC35818 |
يُظهر DC41-SMe ، أحد مشتقات DC1 ، السمية الخلوية في خلايا Ramos و Namalwa و HL60 / s مع IC50s تتراوح من 18-25 ميكرومتر. DC1 ، نظير مبسط لـ CC-1065 ، هو جسم مضاد مترافق من ألكيلات الدنا السامة للخلايا من أجل العلاج المستهدف للسرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1354787-71-5
Sample solution is provided at 25 µL, 10mM.
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DC41-SMe is a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].
[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.
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