Diazepinomicin (Synonyms: ECO-4601; TLN-4601; BU 4664L) |
| رقم الكتالوجGC35859 |
الديازيبينوميسين (TLN-4601) هو مستقلب ثانوي ينتجه Micromonospora spيثبط الديازيبينوميسين (TLN-4601) مسار إشارات Ras-ERK MAPK المستحث بـ EGF ويحفز موت الخلايا المبرمجعامل مضاد للورم لنماذج K-Ras mutant
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Cas No.: 733035-26-2
Sample solution is provided at 25 µL, 10mM.
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Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models[1]. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway post Ras prenylation and prior to MEK activation[1].
[1]. Campbell PM, et al. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal. 2010 Nov 2;5:18.
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