Mardepodect |
| رقم الكتالوجGC36540 |
Mardepodect (PF-2545920) هو مثبط فعال وفعال عن طريق الفم وانتقائي PDE10A مع IC50 من 0.37 نانومتر ، مع انتقائية أكثر من 1000 ضعف على أجهزة PDE الأخرى
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 898562-94-2
Sample solution is provided at 25 µL, 10mM.
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Mardepodect (PF-2545920) is a potent and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.
[1]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196. [2]. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590.
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