MD2-TLR4-IN-1 |
رقم الكتالوجGC36578 |
MD2-TLR4-IN-1 (المركب 22 م) هو مثبط لبروتين التمايز النخاعي 2 / مستقبلات تشبه الرقم 4 (MD2-TLR4) ، مما يثبط التعبير الناجم عن عديدات السكاريد الدهنية (LPS) عن عامل نخر الورم ألفا (TNF-α) و interleukin-6 (IL-6) في الضامة بقيم IC50 0.89 ميكرومتر و 0.53 ميكرومتر على التوالي
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Cas No.: 2249801-12-3
Sample solution is provided at 25 µL, 10mM.
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1]. MD2-TLR4[1].
[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.
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