MT-802 |
| رقم الكتالوجGC36661 |
MT-802 عبارة عن مطهر قوي لـ BTK يعتمد على Cereblon ligand ، مع DC50 من 1 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2231744-29-7
Sample solution is provided at 25 µL, 10mM.
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MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1]. DC50: 1 nM (BTK)[1].
MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].
[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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