Nimustine hydrochloride (Synonyms: ACNU, NSC-D 245382) |
| رقم الكتالوجGC36743 |
Nimustine hydrochloride (ACNU) هو عامل ربط متقاطع للحمض النووي وعامل ألكلة للحمض النووي ، والذي يحفز آفات منع تكرار الحمض النووي وفواصل الحمض النووي المزدوج وتثبيط تخليق الحمض النووي ، الذي يشيع استخدامه في العلاج الكيميائي للأورام الأرومية الدبقية
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Cas No.: 55661-38-6
Sample solution is provided at 25 µL, 10mM.
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Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3].
[1]. Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6(32):33755-68. [2]. Kondo N, et al. FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One. 2011 May 9;6(5):e19659. [3]. Mineura K, et al. DNA lability induced by nimustine and ramustine in rat glioma cells. J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1391-4.
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