PK68 |
| رقم الكتالوجGC36933 |
يعتبر PK68 مثبطًا فعالًا ومحددًا من النوع الثاني للكيناز المتفاعل مع المستقبلات (RIPK1) مع IC50 من 90 نانومتر تقريبًا ، ويعرض تثبيط التنخر المعتمد على RIPK1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2173556-69-7
Sample solution is provided at 25 µL, 10mM.
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PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis[1]. IC50: ~ 90 nM (RIPK1)[1]
[1]. Hou J, et al. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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