SOS1-IN-2 |
رقم الكتالوجGC37667 |
SOS1-IN-2 (المركب I-6) هو مثبط فعال عن طريق الفم وفعال للغاية وانتقائي للتفاعل بين KRAS وابن Sevenless 1 (SOS1) مع IC50 من 6 نانومتر. يقلل SOS1-IN-2 بشكل فعال من تكوين KRAS المحملة بـ GTP ، ويمنع إشارات مسار MAPK. SOS1-IN-2 له نشاط مضاد للسرطان.
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Cas No.: 2230836-55-0
Sample solution is provided at 25 µL, 10mM.
SOS1-IN-2 is a Son of Sevenless 1 (SOS1) inhibitor extracted from patent WO2018115380A1, compound I-6, and it has an IC50 of 6 nM[1]. IC50: 6 nM (SOS1)[1]
[1]. Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
Average Rating: 5
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