LDN-192960 hydrochloride |
| رقم الكتالوجGC38403 |
هيدروكلوريد LDN-192960 هو مثبط لـ Haspin و Kinase 2 المنظم بالتيروزين (DYRK2) مع IC50s من 10 نانومتر و 48 نانومتر ، على التوالي
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Cas No.: 2309172-48-1
Sample solution is provided at 25 µL, 10mM.
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LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].
LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μM), including CLK1 (IC50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1].
[1]. Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.
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