Gefitinib impurity 2 |
| رقم الكتالوجGC60869 |
النجاسة جيفيتينيب 2 هي شوائب جيفيتينيب
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Cas No.: 246512-44-7
Sample solution is provided at 25 µL, 10mM.
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Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; ) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. [2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.
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