Itanapraced (CHF5074) (Synonyms: CS 1103, CSP1103, Itanapraced) |
| رقم الكتالوجGC30954 |
Itanapraced (CHF5074) (CHF5074) هو γ جديد ؛ -مُحَوِّل secretase ، يقلل Aβ ؛ 42 و Aβ ؛ 40 إفراز ، مع IC50 من 3.6 و 18.4 μ ؛ M ، على التوالي.
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Cas No.: 749269-83-8
Sample solution is provided at 25 µL, 10mM.
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Itanapraced (CHF5074) is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
[1]. Imbimbo BP, et al. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830. [2]. Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.
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