JS-K |
| رقم الكتالوجGC18734 |
JS-K هو مانح NO يتفاعل مع الجلوتاثيون لتوليد NO عند درجة الحموضة الفسيولوجية. JS-K يمنع التكاثر ، ويحفز موت الخلايا المبرمج ، ويعطل دورة الخلية لخلايا سرطان الدم الليمفاوي الحاد Jurkat T.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 205432-12-8
Sample solution is provided at 25 µL, 10mM.
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JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. It inhibits proliferation of HL-60 cells (IC50 = 0.5 uM), which is prevented by the glutathione precursor N-acetyl-L-cysteine , and inhibits growth of the solid tumor cell lines PPC-1, DLD-1, and Meth A. It decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 uMol/kg, i.v., three times per week. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells. It also induces S-nitrosylation of β-catenin followed by dose-dependent degradation of nuclear β-catenin and S-nitrosylated nuclear β-catenin levels.
Review for JS-K
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
Review for JS-K
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