Methylprednisolone (Synonyms: Medesone, Medrol, Noretona, NSC 19987, U-7532) |
| رقم الكتالوجGC15505 |
Methylprednisolone is a corticosteroid that interacts with the glucocorticoid receptor and inhibits cortisol secretion with an IC50 of 1.7ng/ml.
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Cas No.: 83-43-2
Sample solution is provided at 25 µL, 10mM.
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Methylprednisolone is a corticosteroid that interacts with the glucocorticoid receptor and inhibits cortisol secretion with an IC50 of 1.7ng/ml [1]. Methylprednisolone exerts anti-inflammatory effects by inhibiting NF-kappaB and can be utilized in the treatment of tuberculosis and COVID-19 [2].
Methylprednisolone (0.5µM, 5µM, 30µM, or 50µM) could reduce HOG cell proliferation and promote HOG death in a dose-dependent manner. Methylprednisolone also decreased the expression of MBP, a marker for early mature oligodendrocytes, and inhibited myelin regeneration [3].
Methylprednisolone (25mg/kg) treatment significantly ameliorated l Aβ1-42-induced cognitive deficits in Alzheimer's disease mice as well as reduced microglia hyperactivation. Synaptic function-related genes could be upregulated by Methylprednisolone, while immune response-related genes were suppressed by Methylprednisolone. Methylprednisolone alleviated cognitive dysfunction by improving synaptic function and suppressing immune and inflammatory processes [4].
References:
[1]. Lew KH, Ludwig EA, Milad MA, Donovan K, Middleton E Jr, Ferry JJ, Jusko WJ. Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1993 Oct;54(4):402-14. doi: 10.1038/clpt.1993.167. PMID: 8222483; PMCID: PMC4207261.
[2]. Li A, He Y, Yang C, Lu N, Bao J, Gao S, Hosyanto FF, He X, Fu H, Yan H, Ding N, Xu L. Methylprednisolone Promotes Mycobacterium smegmatis Survival in Macrophages through NF-κB/DUSP1 Pathway. Microorganisms. 2023 Mar 16;11(3):768. doi: 10.3390/microorganisms11030768. PMID: 36985341; PMCID: PMC10058212.
[3]. GÓmez-Pinedo U, MatÍas-Guiu JA, Ojeda-Hernandez D, de la Fuente-Martin S, Kamal OM, Benito-Martin MS, Selma-Calvo B, Montero-Escribano P, MatÍas-Guiu J. In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies. Cells. 2023 May 30;12(11):1515. doi: 10.3390/cells12111515. PMID: 37296635; PMCID: PMC10252523.
[4]. Sun Y, Li J, A N, Li Z, Zhong W, Chen L, Liu S, Zhang B, Zhu Z, Li X. Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer's disease. Front Immunol. 2023 May 1;14:1192940. doi: 10.3389/fimmu.2023.1192940. PMID: 37197654; PMCID: PMC10183590.
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