ML311 |
| رقم الكتالوجGC33312 |
ML311 هو مثبط قوي وانتقائي لتفاعل Mcl-1 / Bim
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315698-17-0
Sample solution is provided at 25 µL, 10mM.
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ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1].
[1]. Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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