Pentosidine |
| رقم الكتالوجGC40914 |
المنتجات النهائية المتقدمة للجلايكوز (AGEs) هي مركبات تشكل بعد ردود فعل كيميائية غير إنزيمية على ارتباط السكر بالبروتينات أو الدهون خلال مرض السكري وفشل الكلى والشيخوخة وآثار التهاب المفاصل وغيرها من الحالات.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 124505-87-9
Sample solution is provided at 25 µL, 10mM.
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Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.[3]
Reference:
[1]. Neeper, M., Schmidt, A.M., Brett, J., et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. The Journal of Biological Chemisty 267(21), 14998-15004 (1992).
[2]. Brett, J., Schmidt, A.M., Yan, S.D., et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. American Journal of Pathology 143(6), 1699-1712 (1993).
[3]. Miyata, T., Ueda, Y., Horie, K., et al. Renal catabolism of advanced glycation end products: The fate of pentosidine. Kidney International 53, 416-422 (1998).
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