PI-273 |
| رقم الكتالوجGC39155 |
PI-273 هو أول مثبط فوسفاتيديلينوسيتول 4-كيناز (PI4KIIα) قابل للعكس ومحدد مع IC50 من 0.47 ميكرومتريمكن أن يمنع PI-273 تكاثر خلايا سرطان الثدي ، ويمنع دورة الخلية ويحفز موت الخلايا المبرمج
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 925069-34-7
Sample solution is provided at 25 µL, 10mM.
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PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis[1].
[1]. Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266.
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