Rebeccamycin (Synonyms: BRN 4732638, NSC 359079) |
| رقم الكتالوجGC44809 |
ريبيكاميسين ، مضاد حيوي مضاد للأورام ، يثبط DNA topoisomerase I. يبدو أن الريبيكاميسين يمارس تأثيره الأساسي المضاد للأورام عن طريق تسميم توبويزوميراز I وله تأثير ضئيل على بروتين كيناز C و topoisomerase II
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Cas No.: 93908-02-2
Sample solution is provided at 25 µL, 10mM.
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Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I. It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells.
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