SCH 336 (Synonyms: SCH-225336) |
| رقم الكتالوجGC50271 |
SCH 336 هو ناهض CB2 قوي وانتقائي وعكسي وفعال عن طريق الفم
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Cas No.: 447459-51-0
Sample solution is provided at 25 µL, 10mM.
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Highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.
Lunn et al (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 316 780 PMID:16258021
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