SNT-207707 |
| رقم الكتالوجGC31600 |
SNT-207707 هو أحد مضادات مستقبلات الميلانوكورتين MC-4 الانتقائية والفعالة عن طريق الفم مع IC50 من 8 نانومتر (ربط) و 5 نانومتر (وظيفة) على مستقبل MC-4
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Cas No.: 1064662-40-3
Sample solution is provided at 25 µL, 10mM.
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SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.
SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1].
Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].
[1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.
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