Spirohexenolide A |
| رقم الكتالوجGC44941 |
Spirohexenolide A is a metabolite originally isolated from S.
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Cas No.: 1193347-22-6
Sample solution is provided at 25 µL, 10mM.
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Spirohexenolide A is a metabolite originally isolated from S. platensis. It inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI-8226 multiple myeloma, HOP-92 lung, and SW620 colon cancer cell lines being most sensitive (GI50s = 254, 191, and 565 nM, respectively). Spirohexenolide A also binds to human macrophage migration inhibition factor (MIF; Kd = 35.9 μM) and inhibits MIF cellular uptake and lysosomal localization in HCT116 cells.
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