TAN 1364B (Synonyms: RK-682 (rac-1)) |
| رقم الكتالوجGC41443 |
TAN 1364B ، زميل سباق من RK-682 ، هو مثبط بروتين فوسفاتيز التيروزين (PTPases). TAN 1364B يثبط البروتين التيروزين الفوسفاتيز 1B (PTP-1B) ، البروتين منخفض الوزن الجزيئي التيروزين الفوسفاتيز (LMW-PTP) ، ودورة الانقسام الخلوي 25B (CDC-25B) مع IC50s 8.6 μ ؛ M ، 12.4 μ ؛ M ، و 0.7 μ ؛ م على التوالي.
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Cas No.: 154639-24-4
Sample solution is provided at 25 µL, 10mM.
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TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
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