TAT-Gap19 |
رقم الكتالوجGC50390 |
TAT-Gap19 ، ببتيد Cx مقلد ، هو مثبط محدد لقناة هيميكسين 43 (Cx43 HC)
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Cas No.: 1507930-54-2
Sample solution is provided at 25 µL, 10mM.
Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 . Active in vivo. Brain penetrant.
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID:25374505 |Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID:25913636
Average Rating: 5
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