TCV-309 chloride |
رقم الكتالوجGC33088 |
كلوريد TCV-309 هو عامل تنشيط قوي ومحدد للصفائح الدموية (PAF)يمنع كلوريد TCV-309 على وجه التحديد التجميع الناجم عن PAF للأرانب والصفائح الدموية البشرية ، و [3H] يرتبط PAF بميكروسومات صفيحات الأرانب بقيم IC من 33 نانومتر و 58 نانومتر و 27 نانومتر ، على التواليكلوريد TCV-309 له آثار مفيدة في صدمة الحساسية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 121494-09-5
Sample solution is provided at 25 µL, 10mM.
TCV-309 chloride is a platelet activating factor (PAF) antagonist. (1) TCV-309 chloride specifically inhibited PAF-induced aggregation of rabbit and human platelets. (2) TCV-309 chloride selectively inhibited the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 (chloride) most potently protected mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. (3) TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
[1]. Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
Average Rating: 5
(Based on Reviews and 10 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *