Tofacitinib metabolite-1 |
| رقم الكتالوجGC60367 |
مستقلب Tofacitinib-1 هو مستقلب من Tofacitinib ، مثبط JAK
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Cas No.: 1640971-51-2
Sample solution is provided at 25 µL, 10mM.
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Tofacitinib metabolite-1 is a metabolite of Tofacitinib , a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2].
[1]. Martin E Dowty, et al. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. [2]. Matthias Gehringer, et al. Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres. ChemMedChem. 2014 Nov;9(11):2516-27.
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