U-74389G (Synonyms: Methylated Tirilazad) |
| رقم الكتالوجGC45108 |
U-74389G (PNU74389G meleate) هو أحد مضادات الأكسدة ، ويمكن أن يمنع تفاعلات بيروكسيد الدهون.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 153190-29-5
Sample solution is provided at 25 µL, 10mM.
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U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.[1],[2],[3],[4]
Reference:
[1]. Ishizaki, N., Zhu, Y., Zhang, S., et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation 63, 202-208 (1997).
[2]. Palma-Vargas, J.M., Toledo, A.H., García-Criado, F.J., et al. 21-Aminosteroids block neutrophil infiltration and provide liver protection independent of nitrite/nitrate levels. Journal of Surgical Research 66, 131-137 (1996).
[3]. Perna, A.M., Liguori, P., Bonacchi, M., et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacological Research 34, 25-31 (1996).
[4]. Shoskes, D.A., Xie, Y., and Gonzalez-Cadavid, N.F. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat. Implications for renal transplantation. Transplantation 63, 495-500 (1997).
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