Utibapril (FPL 63547) |
| رقم الكتالوجGC32534 |
Utibapril (FPL 63547) هو مثبط للإنزيم المحول للأنجيوتنسين (ACE) مع أنشطة خافضة للضغط.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 109683-61-6
Sample solution is provided at 25 µL, 10mM.
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Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.
Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].
[1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. [2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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