Rilpivirine-d6 (hydrochloride) |
| رقم الكتالوجGC48053 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Rilpivirine-d6 is intended for use as an internal standard for the quantification of rilpivirine by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM.1 It is active against NNRTI-resistant HIV strains with EC50 values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = <10 nM), including strains containing up to eight resistance mutations. In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine , and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.2
1.Garvey, L., and Winston, A.Rilpivirine: A novel non-nucleoside reverse transcriptase inhibitorExpert Opin. Drug Discov.18(7)1035-1041(2009) 2.Arainga, M., Edagwa, B., Mosley, R.L., et al.A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapyRetrovirology14(1)17(2017)
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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