RORγt inverse agonist 13 |
| رقم الكتالوجGC62349 |
RORγ ؛ ناهض معكوس 13 (المركب 3i) هو ناهض عكسي قوي ونشط عن طريق الفم وانتقائي RORγ ؛ مع خصائص شبيهة بالعقاقير محسنة ، مع IC50 من 63.8 نانومتر.
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Cas No.: 2170477-75-3
Sample solution is provided at 25 µL, 10mM.
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RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1].
RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 µM in Th17 cell differentiation assay[1].
RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].
[1]. Nannan Sun, et al. Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists. Eur J Med Chem. 2020 Jul 5;202:112536.
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