RP-54745 |
| رقم الكتالوجGC31804 |
RP-54745 هو مثبط لتحفيز البلاعم وإنتاج الإنترلوكين -1 ، ومركب محتمل مضاد للروماتيزم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 135330-08-4
Sample solution is provided at 25 µL, 10mM.
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RP 54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
RP 54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1].
RP 54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP 54745[2].
[1]. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. [2]. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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