RP 70676 |
| رقم الكتالوجGC30438 |
RP 70676 هو مثبط قوي لـ ACAT ، مع IC 50 من 25 و 44 نانومتر للفئران والأرانب ACAT.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 136609-26-2
Sample solution is provided at 25 µL, 10mM.
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RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT.
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM.
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits[1].
[1]. M.J. Ashton, et al. RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT). Bioorganic & Medicinal Chemistry Letters Volume 2, Issue 5, 1992, Pages 375-380.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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