Rubratoxin A (Synonyms: BRN 1633008, HSDB 3532) |
| رقم الكتالوجGC40285 |
Rubratoxin A هو سم فطري طبيعي ومثبط تنافسي لبروتين فوسفاتيز 2A (PP2A) مع IC50 من 170 نانومتريسبب Rubratoxin A قمع ورم خبيث الورم وتقليل حجم الورم الأولي في xenografts الماوس
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Cas No.: 22467-31-8
Sample solution is provided at 25 µL, 10mM.
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Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 µM. It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.
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