S-Acetyl-L-glutathione (Synonyms: S-Acetylglutathione) |
| رقم الكتالوجGC46215 |
A derivative of glutathione
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3054-47-5
Sample solution is provided at 25 µL, 10mM.
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S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases survival in a mouse model of HSV-1 infection.
|1. Okun, J.G., Sauer, S., B•hr, S., et al. S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. J. Inherit. Metab. Dis. 27(6), 783-786 (2004).|2. Locigno, R., Pincemail, J., Henno, A., et al. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int. J. Oncol. 20(1), 69-75 (2002).|3. Vogel, J.-U., Cinatl, J., Dauletbaev, N., et al. Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection. Med. Microbiol. Immunol. 194(1-2), 55-59 (2005).
| Cas No. | 3054-47-5 | SDF | |
| المرادفات | S-Acetylglutathione | ||
| Canonical SMILES | OC([C@@H](N)CCC(N[C@@H](CSC(C)=O)C(NCC(O)=O)=O)=O)=O | ||
| Formula | C12H19N3O7S | M.Wt | 349.4 |
| الذوبان | PBS (pH 7.2): 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.862 mL | 14.3102 mL | 28.6205 mL |
| 5 mM | 0.5724 mL | 2.862 mL | 5.7241 mL |
| 10 mM | 0.2862 mL | 1.431 mL | 2.862 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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