(S)-Bromoenol lactone (Synonyms: (S)BEL) |
| رقم الكتالوجGC40679 |
(S) -Bromoenol lactone ((S) -BEL) هو مثبط لا رجعة فيه ، حلزوني ، قائم على آلية من فوسفوليباز A2β المستقل عن الكالسيوم (iPLA2β) الذي يثبط إطلاق الأراكيدونات الناجم عن الفازوبريسين من العضلات الملساء الأبهر الجرذ المستزرع (A10) الخلايا ذات IC 50 من 2 ميكرومتر
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Cas No.: 478288-94-7
Sample solution is provided at 25 µL, 10mM.
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The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM. (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.
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