S-(+)-Marmesin ((+)-Marmesin) (Synonyms: (+)-Marmesin, (S)-Marmesin, NSC 340840) |
| رقم الكتالوجGC30027 |
S- (+) -Marmesin ((+) -Marmesin) عبارة عن كومارين طبيعي يظهر نشاط مثبط مزدوج لـ COX-2/5-LOX.
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Cas No.: 13849-08-6
Sample solution is provided at 25 µL, 10mM.
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S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
S-(+)-Marmesin ((+)-marmesin) shows affinity at the recombinant psoralen synthase, with a Km of 1.5 ± 0.5 μM, exceeding the substrate affinities of other enzymes of the CYP71 subfamily involved in plant secondary metabolism[1]. S-(+)-Marmesin ((+)-marmesin) shows COX-2/5-LOX dual inhibitory activity[2].
[1]. Larbat R, et al. Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. J Biol Chem. 2007 Jan 5;282(1):542-54. Epub 2006 Oct 26. [2]. Kim JS, et al. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharm Res. 2006 Aug;29(8):617-23.
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