S1R agonist 1 hydrochloride |
| رقم الكتالوجGC71102 |
S1R agonist 1 hydrochloride هو ناشر S1R انتقائي مع كيس من 0.93 نانومتر و 72 نانومتر لكل من S1R و S2R على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 242487-82-7
Sample solution is provided at 25 µL, 10mM.
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S1R agonist 1 (Compound 6b; 0.1-5 μM) hydrochloride significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner in PC12 cell lines[1].
S1R agonist 1 (24 h) hydrochloride significantly prevents cell damage induced by Rotenone when tested at the concentration of 1 μM in SHSY5Y cells[1].
S1R agonist 1 (0.1-5 μM; 24 h) hydrochloride demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells[1].
S1R agonist 1 (0-10 μM; 24-72 h) hydrochloride shows no cytotoxicity against A549, LoVo and Panc-1 cells[1].
S1R agonist 1 (Compound 6b; 0.1-50 μM; 120 h) hydrochloride induces the death of 4 Zebrafish embryos out of 8 at 10 μM[1].
References:
[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.
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